microRNA?146a and ?155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS?CoV?2 oral receptor genes

Background Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Recent studies show upregulation innate immuno-regulatory microRNA-146a -155 in oral fluids patients with type as well periodontitis. The aim was investigate whether these microRNAs may relate patient susceptibility the infection via modulation SARS-CoV-2 cellular entry factors expression. Methods Due limited experimental feasibility health risks Coronavirus Disease 2019, bioinformatic analyses combining system biology were used initial investigation interaction between microRNA-146 genes encoding factors. Results are expressed salivary glands masticatory mucosa (tongue) at different expression levels, comparable those measured lungs tonsil. MicroRNA-146 widely involved regulation enhance ACE2 modulate host immunity. Conclusions Diabetes- periodontitis-induced increase cavity is predicted upregulate angiotensin-converting enzyme expression, essential receptors, antiviral response. As it could suggest increased infectivity patients, additional protective measures for periodontists recommended.